Is Gluten Intolerance and Wheat Allergy the Same Thing?

Is Gluten Intolerance and Wheat Allergy the Same Thing?

In case you haven’t heard, going on a gluten-free diet is trendy. For at least 1% of the population going gluten-free is essential for good health. That’s because they have a condition called celiac disease that’s exacerbated by eating even small amounts of dietary gluten, proteins found in cereal grains. The two most common gluten proteins are gliadin and glutenin. It’s these proteins that give bread its strength, elasticity, and ability to rise when you bake it. Gluten serves a useful purpose but some people can’t tolerate it. For those with celiac disease, consuming gluten can have devastating consequences.

Celiac Disease and Gluten Intolerance

Celiac disease is an autoimmune disease marked by inflammation and damage to the small intestines brought on by consuming gluten. It has a strong genetic component and the only treatment is to avoid foods containing gluten such as wheat, rye, barley, and its derivative, including a hybrid between wheat and rye called triticale. People with celiac disease who don’t eliminate gluten can have problems absorbing nutrients and ongoing intestinal inflammation. They’re also at higher risk for cancer of the intestinal tract and infertility.

Health professionals now realize that up to 10% of the population is intolerant of or sensitive to the gluten in wheat, rye, and barley. These folks don’t experience the small intestinal damage and inflammation that people with celiac do, but they have intestinal symptoms as well as other symptoms unrelated to the intestinal tract when they eat gluten-containing foods. These symptoms may include bloating, flatulence, feeling tired, brain fog, or headache, among others. People sometimes refer to non-celiac gluten intolerance as a wheat allergy, although this is a misnomer.

Wheat Allergy versus Gluten Intolerance

Wheat allergy is not the same thing as gluten intolerance. A wheat allergy is characterized by a heightened immune response to one or more of the proteins in wheat. Just as people have allergies to seafood or peanuts, to name a few, you can be allergic to the proteins in wheat. When you have a wheat allergy, your body produces a type of antibody called IgE against one or more of the proteins in wheat.

When you have IgE antibodies directed against wheat proteins, your body mounts an immune response when you’re exposed to wheat. The response can be mild, such as hives, or deadly. In severe cases, you might experience difficulty breathing, swelling of the face and throat, or even got into shock when you consume wheat. People with wheat allergies may experience intestinal symptoms like abdominal cramping or diarrhea, but unlike celiac disease, a wheat allergy doesn’t cause ongoing intestinal inflammation. Other common symptoms of an allergy to wheat are watery eyes, headaches, nausea, achy joints. People who have a wheat allergy are often allergic to other foods as well.

Interestingly, if you have a wheat allergy, you can still eat other gluten-containing grains, including barley and rye, as long as the food is free of wheat. Gluten itself is not what causes the reaction – it’s other proteins in wheat. However, keep in mind that around 20% of kids with a wheat allergy are also allergic to other grains.

Avoiding Wheat is Challenging

Wheat allergies are one of the nine more common causes of food allergies, along with eggs, soy, tree nuts, peanuts, fish, shellfish, sesame, and milk. Unfortunately, avoiding wheat is difficult if you eat packaged foods. Items you might not suspect, including baking powder, beer, sauces, hydrolyzed vegetable protein, salad dressings, and more contain wheat. Even non-food items can contain enough wheat to cause a reaction if you’re very sensitive. So, you have to be well-educated about wheat allergies and what to stay away from or avoid packaged foods entirely.

Fortunately, it’s gotten easier to avoid wheat. Federal law now requires all packaged foods in the United States must list “wheat” on the ingredient list if any is in the product. Even though you can eat whole grains that are free of wheat if you have a wheat allergy, some whole grains are cross-contaminated with wheat, so it may be easier and safer to go completely gluten-free.

Another way gluten intolerance and wheat allergies differ is, unlike non-celiac gluten intolerance, testing is available. Blood tests and skin tests are used diagnostically to determine if you have a wheat allergy. You can also get blood tests for celiac disease although the most accurate test is a small intestinal biopsy. There is no blood or skin testing for gluten intolerance. The best way to find out if you have a non-celiac gluten sensitivity is to remove all gluten from your diet for three weeks and see if your symptoms improve.

The Bottom Line

Celiac disease, wheat allergy, and non-celiac gluten intolerance are three distinct entities, although they’re all diet related and improve once you remove the problem substance from your diet. If you suspect you have one of these problems, first get tested for celiac disease and wheat allergy. If your tests show you probably don’t have these conditions, remove all traces of gluten from your diet for three weeks and monitor your symptoms. If your symptoms go away, you are likely sensitive to gluten and should avoid it.

Always get tested for celiac disease before going on a gluten-free diet. If you stop eating gluten beforehand, the test may be falsely negative. Your own health care practitioner can give you further guidance on what tests you need and how to get them. If you’re having digestive symptoms or other symptoms you can’t explain, testing for celiac disease and food allergies, in general, is a smart idea.



Food Allergy: Research and Education. “Wheat Allergy”

Celiac Foundation. “What is Celiac Disease?

Medscape News and Perspective. “Gluten Sensitivity”

Expert Rev Gastroenterol Hepatol. 2012;6(1):43-55.


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