Growth hormone is an anabolic hormone that, strangely enough, has a catabolic effect on fat tissue. It stimulates muscle growth AND boosts fat burning. With those kinds of benefits, no wonder you want growth hormone release to be optimized if you’re trying to get leaner and more defined.
You’ve probably read about non-prescription supplements that supposedly boost growth hormone but there’s no real evidence that they work Plus, the potential risks of taking them outweigh the benefits. Despite this, manufacturers promote them an anti-aging panacea and a way to recoup energy and build lean body mass.
As you know, the best way to build and retain lean body mass is to work your muscles against resistance – and that means strength training using barbells, dumbbells, or resistance bands. You may have also heard that strength training itself boosts the release of growth hormone – is there any truth to this? First, let’s look at where growth hormone comes from.
It All Starts in the Brain
A small gland in your brain called the pituitary releases growth hormone into the bloodstream. However, it does so under the watchful eye of another portion of the brain called the hypothalamus. The hypothalamus secretes two hormones that instruct the pituitary when to release growth hormone. One is called growth hormone-releasing hormone. This hormone tells the pituitary to dump more growth hormone into the circulation.
The second is somatostatin, a hormone that blocks the release of growth hormone from the pituitary. The interplay between these two hormones determines how much growth hormone is in your bloodstream at any one time. When blood levels of growth hormone climb too high, it feeds back to the pituitary and hypothalamus and blocks the release of more.
What else affects your level of growth hormone? Diet, age, stress level, sleep, and other hormones. Growth hormone production is highest in kids (makes sense since they’re growing) and falls by almost half during adulthood. As you enter the second half of life, growth hormone declines even further. Sleep also impacts its release. Growth hormone production is the greatest during the deep stages of sleep. So, not getting enough shut-eye can lower your level of growth hormone.
How Growth Hormone Boosts Muscle Growth
One way in which growth hormone stimulates muscle growth is indirectly through the effects of IGF-1, also known as insulin-like growth factor one. IGF-1 is produced by the liver and goes up in response to growth hormone and in the presence of higher levels of insulin. In many ways, IGF-1 behaves similarly to insulin. One of its functions is to help carry amino acids into muscle cells so they can use them as building blocks for new muscle tissue.
IGF-1 also stimulates the growth of bone, cartilage, nerves, skin, and cells. The fact that IGF-1 promotes cell growth raises concerns about it has the potential to promote the growth of cancer. According to some studies, higher levels of IGF-1 may enhance the risk of developing some cancers. You can also alter IGF-1 through diet. Diets higher in protein, particularly meat and dairy, increase it. Calorie restriction and a vegetarian diet decrease it. IGF-1 is the intermediary by which growth hormone exerts its effect on muscle tissue. IGF-1 is not responsible for the fat-burning effects of growth hormone as fat cells don’t have receptors for IGF-1.
Exercise and The Release Of Growth Hormone
As mentioned, there’s the idea that exercise itself can boost growth hormone, at least temporarily. Is this idea backed by science?
A study published in the American Journal of Physiology-Endocrinology and Metabolism supports this. Researchers divided women into groups, one group did upper body training and the other a total body strength-training workout. Some of the participants used lighter weights and high reps (up to 12 reps before failure) while the other used heavy weights (up to 8 reps before failure). The researchers measured the growth hormone levels of the participants before and after. The women did, indeed, have more growth hormone in their blood after the workouts and levels were higher after using heavier weights.
In another study, researchers from Japan documented a transient rise in growth hormone in 16 participants after a high-intensity interval training session. The participants pedaled an exercise bike at 85% of their V02 max for one minute with 30 seconds of rest between each set. They completed 10 sets in total. So, strength training, using heavy weights, and high-intensity exercise seem to boost growth hormone short term.
Above the Lactate Threshold
The key to ramping up growth hormone release during a workout is to push hard enough to go above the lactate threshold. That means pushing yourself to the near max during the active intervals of HIIT training. There also appears to be a time threshold. A study published in Sports Medicine showed at least 10 minutes of high-intensity exercise is the minimum needed to elicit a growth hormone response. In fact, the build-up of lactate may incite the release of growth hormone. Moderate-intensity, steady-state exercise doesn’t seem to offer the same growth hormone boost as heavy strength training or HIIT training. In fact, long periods of steady-state exercise can boost cortisol, the stress hormone that breaks down muscle tissue.
So, yes, heavy strength training and high-intensity interval training cause a transient rise in growth hormone. The question is whether these increases are enough to boost muscle gain or help with fat loss. Based on the study published in Sports Medicine, researchers propose that high-intensity exercise above the lactate threshold MAY increase the normal pulsatile release of growth hormone over a 24-hour period after a workout. Therefore, you may get more sustained releases in growth hormone after a workout, although this isn’t proven.
The Bottom Line
Growth hormone levels decrease with age and this decline contributes to muscle and bone loss. Low levels of growth hormone are also linked with depression, fatigue, hair loss, and cognitive changes, all problems that become more common with age. High-intensity exercise and heavy strength training, along with a diet that contains sufficient protein and adequate sleep, may help offset some of the age-related decline in the release of growth hormone and IGF-1. So, keep on pushing yourself when you train!
References:
WebMD. “Human Growth Hormone”
J Clin Invest. 2004 Jan 1; 113(1): 25–27 doi: 10.1172/JCI200420660.
Science Daily. “Varying Weight Training Intensity Increases Growth Hormone in Women”
Medicine & Science in Sports & Exercise, February 8, 2011.Aging Male. 2017 Mar;20(1):54-59. doi: 10.1080/13685538.2016.1260108. Epub 2016 Dec 31.
Front Horm Res. 2016;47:1-11. doi: 10.1159/000445147. Epub 2016 Jun 27.
Supversity. “HIIT Increases Post-Workout Growth Hormone and Sheds a Marginal Amount of Body Fat, While LISS Decreases GH and Does Nothing for the Physique of Previously Sedentary Men”
Harvard University Gazette. “Growth Factor Raises Cancer Risk”
Mol Pathol. 2001 Oct; 54(5): 311–316.
Sports Med. 2003;33(8):599-613.
Related Articles By Cathe:
Growth Hormone and Exercise: What Role Does It Play?
What Role Does Growth Hormone Play in Building Lean Body Mass?
Metabolic Aging: How Key Hormones Are Affected by Aging
5 Hormones That Impact Muscle Growth and How They Work
Does Your Metabolism Have to Decrease With Age?
