I went on Accutane two years ago as a last resort for the cystic acne I developed as an adult. It was a pain having to get monthly bloodwork, but my only real side effect was dry lips. I used Aquaphor constantly, and it was bearable and totally worth it for me. I started seeing results really quickly, and once I completed the cycle, it completely eliminated my acne for about a year. When I went off the pill, though, I had a mild-to-moderate flare-up that lasted for several weeks and eventually cleared up again. Now within the past month, I've curiously started breaking out along the jawline again. If it doesn't clear up on its own in a couple of weeks, then I suppose I may be a candidate for a second round.
Good luck! I hope a single round is effective for you.