Yes I have. You are right, it takes a long time to fill the tube so plan when you will be home for the day, a Saturday or Sunday perhaps. Mine was prescribed by my doctor and when I had my 4 samples, I dropped it off at a pharmacy who works in this, is it called biodenticals. You answer a lot of questions on a form about things you are experiencing like new allergies, not sleeping, etc. They send it off and get the results back and then they notified my doctor. I was prescribed an estrogen cream and progesterone pills which needed to be mixed up by the pharmacist, they were compounds. Now I only use the estrogen cream. I redid a blood test 3 months afterwards to check my levels and my progesterone had changed enough to stop. We'll see if it is still good in another month. Hope this helps.