I wouldn't say I'm in a constant state of DOMS, but the first week of any new rotation or routine is not fun. I also have fatigue when I have to take a break from working out and then jump back into it. If I try to jump straight back into a routine with full intensity(even if it's only been a week), my body is unhappy. And when I try a new routine, I feel more DOMS.
I have also figured out that doing 5 workouts per week vs 6 workouts per week helps me with recovery and general fatigue. While I like the effects of the 5 days vs 6, some rotations really needs 6 days to be effective. I'm guessing XTrain will be one of them. I'll have to see how things go.