Two days a week full-body toning may be sufficient for some people (beginners, younger folks who have natural growth hormones working in their favor, someone looking just to "maintain"), but I think for many people, it's good to progress to three days a week (for most weeks---I wouldn't do a two-day split only one time per week each workout, unless I were very muscular and had developed as much as I wanted and were just looking to maintain) or even four days a week (if you do a two-day split0). It also depends on what else you are doing. If you run, for example, that could be considered a lower body workout in itself. As could some step workouts like the IMAXes or LowMax.
I personally don't have a "typical" week, as I change my routines quite often.
When I'm focusing on building, I prefer a three-day split, going heavy, and alternating days of weights and cardio. GS would work well for this (I also like P90X for this). But I also try to get in another leg-intensive workout (a plyometric workout or an IMAX) in the week, to work the legs twice.
When I don't have the gumption to do the above, I'll often just alternate a day of cardio with a day of weights, taking a break as needed (and if I still have DOMS when it's weight day again, I either do a different workout, or take that as my day off).
I will sometimes do both cardio and weights on the same day. If I'm short on time, I'll do an upper/lower body split routine (30 minutes each), each one twice a week (4 days a week total), combined with 45 minutes or so of cardio.
Different things work for different people, especially depending on their goals (to be as buff and muscular as you can be? to be strong, but not big? to maintain what you have? as a supplement to sports or other workouts, to maintain muscular balance?) Tell us what YOUR goals are, and we'll be able to give you some better input!
