RE: Texas governor mandates STD vaccine for all school ...
Let me preface this by stating that these are my thoughts based on what I've found on genital HPV and the vaccine. I encourage parents and women considering the vaccine to research.
As a parent, I am undeided about this vaccine. If my DD remains chaste (no genital activity) until marriage, what are the chances she will marry a man with the same history? HPV testing is limited to females and specific strains, so this isn't something to test for before beginning an intimate relationship. Condoms reduce transmission of HPV but protection is limited (NEJM).
With that said, I also consider the potential benefits of this vaccine to public health. Mandatory vaccinations for school are established to protect students from diseases transmitted through casual contact (sneezing, touching). Genital HPV is primarily sexually transmitted (through genital contact), although non-sexual transmission is possible. However, genital HPV is a concern in public health with as many as 80 percent of women infected with genital HPV by the age of 50. Thankfully, most genital HPV goes away on its own (~90%). There is also the cost-benefit to consider. The treatment alone for genital "HPV infection in 15-24 y/o females, including follow-up for abnormal screenings, is estimated at ~$3 billion per year". I am eager to see an analysis. But, mandating this vaccine is premature IMO, which even the American Academy of Pediatrics agrees with a go-slow approach.
I support voluntary vaccinations. The vaccine is promising. It may prevent cervical cancer, abnormal paps, genital warts (~1 million new cases/year). "The real benefits of this are going to be cancer reduction globally, but, in the U.S., it's going to be its effects on abnormal Pap smears," Columbia University pathologist Thomas Wright said. Though fewer than 10,000 women in the USA will be diagnosed with cervical cancer this year, at least 600,000 will be found to have cervical pre-cancers, and about 60% of those are caused by the two cancer-causing HPV types targeted by Gardasil, Wright said. Abnormal Pap smears then lead to more tests and procedures.” USA Today.
If parents review the evidence and want their child vaccinated, I support that. It is mandating I oppose for a few reasons. The HPV vaccine is ~5 years old. Perhaps my status as a DES daugther has left me cautious.
The vaccine has not been proven to prevent cervical cancer, which takes 10-15 years to develop once abnormal cells begin. Even the FDA notes "the study period was not long enough for cervical cancer to develop, the prevention of these cervical precancerous lesions is believed highly likely to result in the prevention of those cancers". It is believed to prevent cancer based on what is "known" about genital HPV and cervical cancer. For what it is worth, HPV is linked to cervical cancer (99.7%) and most experts consider it the cause/necessary for cervical cancer development although no direct link has been shown. “The finding of HPV viral DNA integrated in the majority of cellular genomes of invasive cervical carcinomas supports epidemiologic data linking this agent to cervical cancer; however, direct causation has not been demonstrated.” cancer.gov
There are so many factors to consider that I remain undecided about voluntary vaccination, who is only 6, but mandating this vaccine may be premature IMHO. Let me add, my humble opinion may change as evidence becomes available.
Sources:
http://www.fda.gov/bbs/topics/NEWS/2006/NEW01385.html
http://www.cancer.gov/cancertopics/pdq/prevention/cervical/healthprofessional/allpages
http://www.usatoday.com/news/health/2006-06-08-cervical-cancer-vaccine_x.htm
http://www.ashastd.org/learn/learn_hpv.cfm
http://www.cdc.gov/std/HPV/default.htm
http://www.thehpvtest.com/
http://content.nejm.org/cgi/content/full/354/25/2645
Walboomers JM, Jacobs MV, Manos MM, Bosch FX, et al. Human Papillomavirus is a necessary cause of invasive cervical cancer worldwide. Journal of Pathology 1999; 189: 12-19