I use to take omeprazole once I was diagnosed with GERD, once a day. About a week into it I had horrible symptoms. Light headed, couldn't think clearly, felt something (I don't know what) was going to burst. Had to go to the hospital. Once I was admitted (about 4 hours from the first symptoms) all the symptoms went away. That's how long the drug lasted in my body before it started wearing off. Once you start taking it, it gets into your system more and more, but the initial reaction is about 4 hours.
I was told omeprazole is the most common med for GERD. My doctor told me most people can tolerate it. That they even give this to babies who have acid reflux problems. Unfortunately not me. I decided not to take meds at all after that experience.
I did a lot of research then, and learned DGL (deglycyrrhizinated Licorice) was mostly used by GERD patience. I started on it right away. Had to adjust it to 1/4 tablet every 4 hours, even during the night. My body is very sensitive. You can get them on line cheaper than the vitamin stores or health food stores. I get mine at Vitacost. It's very reasonable in comparison.
Been taking DGL now for over 6 months and reduced the supplement by 1/4 tablet once a day or once every other day. I've learned what my body can eat and what it reacts to.
Every body is different, you just have to find what is right for you.
Janie