Wellbutrin was the drug my DH & I tried. We noticed nothing. (It helped our depressions though.)
So...the cigarettes did NOT act as anti-depressants for either of us since we smoked & developed depressions. Wellbutrin helped the depressions, but did nothing as far as we could see for the smoking.
Which just goes to show again...everyone is different.
By the way, another thing which worked for me was not throwing away my cigarettes. I knew from past efforts that it would panic me. So instead, I kept a pack, opened, telling myself I could smoke or not smoke, it was up to me. It helped a lot.
I almost tried accupuncture. Wish now that I had.
Ruth