I have been working from home for the last 5 years or so as a medical transcriptionist/medical editor. I work for a company based in the United States, work a 40 hour week, M-F, with full benefits.
Working at home has its pros and cons, as does medical transcription, but it has worked out very well for me.
Also, DH works from home. He is in the IT industry. He has been in the industry for over 25 years, but just started working from home in the last 2 years. Again, a 40 hour week, M-F for the most part, with full benefits.