I use only three proactiv products in my problem areas: the skin lightening lotion, the advanced blemish treatment, and the deep cleansing wash. I have combination skin and I suffer from ocasional acne breakouts in my oily areas. I use Dr. Perricone's products in my dry areas along with some other products. But my main skin problem (condition) is rosacea so my skin is sensitive to most acne medications. To the best of my knowledge, you should use the repairing lotion in the morning and the clarifying night cream at night (instead of the repairing lotion), but that is basically your acne prevention regimen. The skin lightening lotion which I use is for problem spots only. You cannot apply it all over your skin. I use a q-tip and I apply just a bit to any brown or pink spot I see. If you use it during the day you should use a lotion with SPF 15 or more over it. The advanced blemish treatment is used the same way, but it is for acne spots only. I hope this helps.