Hi - I have a slight case of scoliosis. It was one of the reasons I stopped running. A lot of my female friends--former runners--had lower disk problems after running for years, so since my spine is slightly askew, I decided not to tempt fate. Besides, a horrible case of piriformis was the straw that broke that camel's back. That's another thread. The bottom line is that I have NO problems doing any of Cathe's tapes. In fact, doing the PS series and MIS has made my back STRONG---that can only be a good thing. But that's just me, and my scoliosis is slight. If yours is more pronounced, I'd check with a good orthopedist (sports medicine type) to make sure. Good luck. Suzanna