I went to college there and grew up in St. Louis - I left there in about 1990. It has grown a lot since then. It really is more of a town than a city. If you are looking for a lot of excitement it will be in short supply there, but you can have a quiet laid back lifestyle living there.
It really depends on where you are coming from. The midwest has pretty awful winters and really hot summers. I live in the NW now and I could never take that weather again.
The town is very nice - the people around the university are very liberal, the rest of the town is very conservative. I managed a restaurant downtown and you really get that small town feeling there. The schools are great and there is a lot of school money there - at least there was back in the day. The west side of town is where it has expanded the last 10 years and that is kind of the 'burbs for them.
Hope this helps - if you want to know more you can ask specific questions. I didn't know if you had kids, etc.
melissa
Missouri is beautiful if you don't mind flat and the cost of living is very manageable there.