4 Supplements That Reduce Insulin ResistanceInsulin resistance is a common problem. Too many people are overweight and eat a diet heavy in processed foods that contain trans fats, bleached flour and high fructose corn syrup. To make matters worse, most Americans are burning the candle at both ends, leaving little time for sleep. All of these factors contribute to insulin resistance. The problem with insulin resistance is it can eventually lead to type 2 diabetes and increase the risk of other health problems such as heart disease.

The most important thing you can do to reduce insulin resistance is to eat a whole food diet consisting of lean protein, fruits, vegetables and healthy fats such as the monounsaturated fats found in nuts and olive oil. Exercise regularly, and get at least seven hours of sleep a night. In addition, there are four supplements that may help to reduce insulin resistance.


A little cinnamon in your cereal could have substantial health benefits. Animal studies and preliminary research in human shows that cinnamon in quantities as little as ½ teaspoon helps to increase insulin sensitivity. The active ingredient in cinnamon allows insulin to more easily do its job of helping glucose enter cells. As a result, the pancreas can produce less. Less circulating insulin means a lower risk of heart disease and less belly fat.

Because cinnamon boosts insulin sensitivity, it’s the perfect spice for diabetics to sprinkle on oatmeal in the morning. More cinnamon isn’t better though. The kind of cinnamon you buy in the supermarket contains coumarin, a compound linked with liver toxicity. Don’t consume more than a teaspoon of cinnamon a day, or buy Ceylon cinnamon that’s much lower in coumarin.

Chromium picolinate

Chromium is a trace mineral that helps insulin attach more easily to receptors on the surface of cells. This helps insulin function better, thereby increasing insulin sensitivity and reducing insulin resistance. Research shows that chromium boosts insulin sensitivity, but whether it helps people who already get enough chromium in their diet is unclear. One of the best sources of chromium is broccoli. Other good sources are grape juice, garlic, onions and tomatoes. You can buy chromium in supplement form, but talk to your doctor first.


Magnesium is involved in more than 300 chemical reactions in the human body. It also helps insulin work better. People who are deficient in magnesium are more likely to have insulin resistance. According to research published in Diabetes, Obesity and Metabolism, magnesium reduces insulin resistance in both normal people and people with type 2 diabetes. The best food sources of magnesium are bran, lentils, tofu, almonds, cashews and split peas. It’s also found in respectable amounts in seafood, coffee and tea. Magnesium deficiencies aren’t common in people who eat a healthy diet, but chronic stress can increase the need for this mineral.

Alpha-Lipoic Acid

Oxidative stress, a situation where cells are damaged by too much oxygen, contributes to insulin resistance. Animal studies show that the antioxidant alpha-lipoic acid reduces oxidative stress and improves insulin function. The best source of alpha-lipoic acid is red meat, but green, leafy vegetables contain this antioxidant as well. There are alpha-lipoic acid supplements on the market, but it’s best to avoid supplementation until further research confirms its benefits in humans.

The Bottom Line?

There are natural ways to reduce insulin resistance and ward off diabetes through altering your diet, and, possibly, by taking certain supplements. Eat a whole food diet that includes lots of non-starchy vegetables, lean protein and healthy fats such as those in olive oil, nuts and fatty fish. Enjoy more magnesium-rich foods, and add a little cinnamon to your coffee to help reduce insulin resistance. And don’t forget to exercise.


Magnes Res. 2004 Jun;17(2):126-36.
Diabetes, Obesity and Metabolism. Volume 13, Issue 3, pages 281-284, March 2011.
Medscape Family Medicine. “Oxidative Stress-Activated Signaling Pathways: Oxidative Stress and Insulin Resistance”
Diabetes Care. 26:3215-3218, (2003).

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4 Responses to “4 Supplements That Reduce Insulin Resistance”

  1. Amanda says:

    I sprinkle some cinnamon on my oatmeal most every morning, but I’m concerned about the liver toxicity issue. I’m not a diabetic, so should I discontinue using cinnamon? I just put it on there for a little extra flavor along with either blueberries or cut up banana.

  2. Amanda says:

    Would love to try Kale but does not seem to be available in Australia – maybe I will have to grow my own!

  3. Amy says:

    I wouldn’t worry about getting too much cinnamon. Coumarin appears to be toxic at high doses to ridents but not humans.
    Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment. Authors
    Lake BG.
    Food Chem Toxicol. 1999 Apr;37(4):423-53.
    BIBRA International, Carshalton, Surrey, UK.

  4. Amy says:

    That should say “Rodents. “

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